Evaluation of Total Antioxidant Capacity (TAS) by Using Fuzzy Logic
Mehmet Yilmaz *
Geodesy Division, Department of Geodesy and Photogrammetry Engineering, Faculty of Engineering, Harran University, 63100, Osmanbey Campus, Sanliurfa, Turkey.
*Author to whom correspondence should be addressed.
Abstract
Oxidative stress reflects an imbalance between the manifestation of systemic detoxification of reactive oxygen species and reactive intermediates or easily a biological system's ability to repair the damage caused. Normal redox peroxides and disorders of cells, proteins, lipids and deoxyribonucleic acid (DNA) of the cell including the free radical damage to all components may lead to toxic effects. Additionally, some reactive oxidative species act as cellular redox signaling messengers. Thus, oxidative stress, may cause disruption in normal cellular signaling mechanisms. Oxidative stress is thought to lead major in neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), Parkinson's disease, Alzheimer's disease, Huntington's disease, and Multiple Sclerosis (MS). Indirect proof by monitoring biomarkers like reactive oxygen species, and reactive nitrogen species production, antioxidant defense indicates oxidative damage might be concerned to the pathogenesis of these diseases, while cumulative oxidative stress with disrupted mitochondrial respiration and mitochondrial damage are related with Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases.
Levels of total antioxidant capacity (TAS) reflect the total effect all antioxidants found in plasma and body fluids. Antioxidants such as albumin, uric acid, ascorbic acid, vitamin E and bilirubin are molecules forming the main contribution to the total antioxidant capacity. In this study, we tried to determine total antioxidant capacity of patients using systolic, diastolic blood pressure and age values of patient.
Keywords: Total antioxidant capacity (TAS), fuzzy logic, ANFIS, systolic and diastolic blood pressure